having no money, home, or job, and living on the streets
After losing his job, he became down and out and had to sleep in the park.
失业后,他变得身无分文、无家可归,不得不在公园里过夜。
sure to lose or fail
The team was down and out after the star player got injured.
在明星球员受伤后,这支队伍注定要失败了。