beginning with the most important or earliest thing
First of all, we need to decide on the date for the meeting.
首先,我们需要确定会议的日期。
introducing the first point in a list or explanation
First of all, let's discuss the budget; then we can move on to other topics.
首先,我们来讨论预算;然后我们可以继续讨论其他议题。