To be so worried or anxious about something that it keeps you awake at night.
I didn't lose sleep over the test because I studied well.
試験のせいで眠れなかったわけではない、私はしっかり勉強していたから。
To be very troubled or concerned about something.
She's been losing sleep over her son's health.
彼女は息子の健康問題で眠れなくなっている。