vicissitude
🇺🇸
/vɪˈsɪsɪtuːd/
🇬🇧
/vɪˈsɪsɪtjuːd/
Ups and downs; changes in life or situations that you have to face
Despite the vicissitudes of life, she remained optimistic.
人生の変化にもかかわらず、彼女は楽観的であり続けた。