vicissitude
🇺🇸
/vɪˈsɪsɪtuːd/
🇬🇧
/vɪˈsɪsɪtjuːd/
Ups and downs; changes in life or situations that you have to face
Despite the vicissitudes of life, she remained optimistic.
인생의 변천에도 불구하고 그녀는 낙관적이었습니다.